Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum.
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Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum
The distribution of acetylated alpha-tubulin in rat cerebellum was examined and compared with that of total alpha-tubulin and tyrosinated alpha-tubulin. From immunoperoxidase-stained vibratome sections of rat cerebellum it was found that acetylated alpha-tubulin, detectable with monoclonal 6-11B-1, was preferentially enriched in axons compared with dendrites. Parallel fiber axons, in particular...
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The distribution of acetylated ct-tubulin in rat cerebellum was examined and compared with that of total ct-tubulin and tyrosinated ¢t-tubulin. From immunoperoxidase-stained vibratome sections of rat cerebellum it was found that acetylated a-tubulin, detectable with monoclonal 6-11B-l, was preferentially enriched in axons compared with dendrites. Parallel fiber axons, in particular, were labele...
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Subsets of microtubules enriched in posttranslationally detyrosinated (Gundersen, G. G., M. H. Kalnoski, and J. C. Bulinski. 1984. Cell. 38:779) or acetylated (Piperno, G., M. Le Dizet, and X. Chang. 1987. J. Cell Biol. 104:298), alpha tubulin have previously been described in interphase cultured cells. In this study an immunofluorescence comparison of these minor populations of microtubules re...
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Tubulin proteins in mouse retinal ganglion cell (RGC) neurons were analyzed to determine whether they undergo posttranslational processing during axoplasmic transport. Alpha- and beta-tubulin comprised heterogeneous proteins in the primary optic pathway (optic nerve and optic tract) when examined by two-dimensional (2D) PAGE. In addition, however, alpha-tubulin exhibited regional heterogeneity ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1987
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.104.6.1569